業績 - Publications -
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TGF-β inhibitor treatment of H₂O₂-induced cystitis models provides biochemical mechanism for elucidating interstitial cystitis/painful bladder syndrome patients.
Taga H, Kishida T, Inoue Y, Yamamoto K, Kotani SI, Masashi T, Ukimura O, Mazda O.
PLoS One. 2023 Nov 6;18(11):e0293983. doi: 10.1371/journal.pone.0293983. eCollection 2023.
PMID: 37931000 -
Raman Fingerprints of SARS-CoV-2 Omicron Subvariants: Molecular Roots of Virological Characteristics and Evolutionary Directions.
Pezzotti G, Ohgitani E, Fujita Y, Imamura H, Pappone F, Grillo A, Nakashio M, Shin-Ya M, Adachi T, Yamamoto T, Kanamura N, Marin E, Zhu W, Inaba T, Tanino Y, Nukui Y, Higasa K, Yasukochi Y, Okuma K, Mazda O.
ACS Infect Dis. 2023 Oct 18. doi: 10.1021/acsinfecdis.3c00312. Online ahead of print.
PMID: 37850869 -
Raman Multi-Omic Snapshot and Statistical Validation of Structural Differences between Herpes Simplex Type I and Epstein-Barr Viruses.
Pezzotti G, Ohgitani E, Imamura H, Ikegami S, Shin-Ya M, Adachi T, Adachi K, Yamamoto T, Kanamura N, Marin E, Zhu W, Higasa K, Yasukochi Y, Okuma K, Mazda O.
Int J Mol Sci. 2023 Oct 25;24(21):15567. doi: 10.3390/ijms242115567.
PMID: 37958551 -
Effects of tea, catechins and catechin derivatives on Omicron subvariants of SARS-CoV-2.
Shin-Ya M, Nakashio M, Ohgitani E, Suganami A, Kawamoto M, Ichitani M, Kobayashi M, Takihara T, Inaba T, Nukui Y, Kinugasa H, Ishikura H, Tamura Y, Mazda O.
Sci Rep. 2023 Oct 3;13(1):16577. doi: 10.1038/s41598-023-43563-3.
PMID: 37789046 -
Milk Casein Inhibits Effect of Black Tea Galloylated Theaflavins to Inactivate SARS-CoV-2 In Vitro.
Nakashio M, Ohgitani E, Shin-Ya M, Kawamoto M, Ichitani M, Kobayashi M, Takihara T, Kinugasa H, Ishikura H, Mazda O.
Bioengineering (Basel). 2023 Sep 9;10(9):1068. doi: 10.3390/bioengineering10091068.
PMID: 37760169 ⇐ （査読付国際科学雑誌、2023年9月公開）
BioRxiv doi: https://doi.org/10.1101/2021.09.27.461930 ⇐ （プレプリント、2021年9月公開） -
Size control of induced pluripotent stem cells colonies in two-dimensional culture for differentiation into functional monocyte-like cells.
Shimasaki N, Shimizu E, Nakamura Y, Iguchi H, Ueda A, Umekage M, Haneda S, Mazda O.
Cytotherapy. 2023 Sep 6:S1465-3249(23)01016-2. doi: 10.1016/j.jcyt.2023.08.002. Online ahead of print.
PMID: 37676216 -
Instantaneous inactivation of herpes simplex virus by silicon nitride bioceramics.
Pezzotti G, Ohgitani E, Ikegami S, Shin-Ya M, Adachi T, Yamamoto T, Kanamura N, Marin E, Wenliang Zhu W, Okuma K, Mazda O.
Int. J. Mol. Sci. 24(16) : 12657. 2023. -
Inactivation of Herpes Simplex Virus by Silicon Nitride Bioceramics.
Pezzotti G, Ohgitani E, Ikegami S, Shin-Ya M, Adachi T, Yamamoto T, Kanamura N, Marin E, Zhu W, Okuma K, Mazda O.
Int J Mol Sci. 2023 Aug 10;24(16):12657. doi: 10.3390/ijms241612657.
PMID: 37628838 -
Hypoxia with or without Treadmill Exercises Affects Slow-Twitch Muscle Atrophy and Joint Destruction in a Rat Model of Rheumatoid Arthritis.
Kamada Y, Arai Y, Toyama S, Inoue A, Nakagawa S, Fujii Y, Kaihara K, Cha R, Mazda O, Takahashi K.
Int J Mol Sci. 2023 Jun 5;24(11):9761. doi: 10.3390/ijms24119761.
PMID: 37298711 -
Anti-Inflammatory Effects of β-Cryptoxanthin on 5-Fluorouracil-Induced Cytokine Expression in Human Oral Mucosal Keratinocytes.
Yamanobe H, Yamamoto K, Kishimoto S, Nakai K, Oseko F, Yamamoto T, Mazda O, Kanamura N.
Molecules. 2023 Mar 24;28(7):2935. doi: 10.3390/molecules28072935.
PMID: 37049698 -
Development of anti-GD2 Antibody-producing Mesenchymal Stem Cells as Cellular Immunotherapy.
Iguchi M, Yagyu S, Kambe K, Higashi M, Fumino S, Kishida T, Iehara T, Mazda O, Tajiri T.
Anticancer Res. 2023 Jun;43(6):2417-2424. doi: 10.21873/anticanres.16409.
PMID: 37247922 -
Prophylactic Application of Human Adipose Tissue-Derived Products to Prevent Radiation Disorders.
Sowa Y, Inafuku N, Kishida T, Mori M, Mazda O, Yoshimura K.
Plast Reconstr Surg. 2023 Jun 1;151(6):1207-1216. doi: 10.1097/PRS.0000000000010132. Epub 2023 Jan 2.
PMID: 36728661 -
Micronized cellular adipose matrix (MCAM) promotes the therapeutic effect of an artificial nerve conduit in peripheral nerve gap injury.
Sawai S, Sowa Y, Kishida T, Inokawa H, Inafuku N, Tsuchida S, Oda R, Fujiwara H, Mazda O, Yoshimura K, Takahashi K.
Plast Reconstr Surg. 2022 Jan 2. doi: 10.1097/PRS.0000000000010136. Online ahead of print.
PMID: 36728688 -
Development of minimally invasive cancer immunotherapy using anti-disialoganglioside GD2 antibody-producing mesenchymal stem cells for a neuroblastoma mouse model.
Kambe K, Iguchi M, Higashi M, Yagyu S, Fumino S, Kishida T, Mazda O, Tajiri T.
Pediatr Surg Int. 2022 Dec 9;39(1):43. doi: 10.1007/s00383-022-05310-z.
PMID: 36484857 -
Three-Dimensional Culture of Cartilage Tissue on Nanogel-Cross-Linked Porous Freeze-Dried Gel Scaffold for Regenerative Cartilage Therapy: A Vibrational Spectroscopy Evaluation.
Adachi T, Miyamoto N, Imamura H, Yamamoto T, Marin E, Zhu W, Kobara M, Sowa Y, Tahara Y, Kanamura N, Akiyoshi K, Mazda O, Nishimura I, Pezzotti G.
Int J Mol Sci. 2022 Jul 22;23(15):8099. doi: 10.3390/ijms23158099.
PMID: 35897669 -
Raman Fingerprints of the SARS-CoV-2 Delta Variant and Mechanisms of Its Instantaneous Inactivation by Silicon Nitride Bioceramics.
Pezzotti G, Ohgitani E, Fujita Y, Imamura H, Shin-Ya M, Adachi T, Yamamoto T, Kanamura N, Marin E, Zhu W, Nishimura I, Mazda O.
ACS Infect Dis. 2022 Aug 12;8(8):1563-1581. doi: 10.1021/acsinfecdis.2c00200. Epub 2022 Jul 12.
PMID: 35819780 -
Raman Molecular Fingerprints of SARS-CoV-2 British Variant and the Concept of Raman Barcode.
G. Pezzotti, F. Boschetto, E. Ohgitani, Y. Fujita, S. Shin-Ya, T. Adachi, T. Yamamoto, N. Kanamura, E. Marin, W. Zhu, I. Nishimura, O. Mazda
Adv Sci (Weinh). 2022 Jan;9(3):e2103287. doi: 10.1002/advs.202103287. Epub 2021 Dec 7. -
ALK5 i II Accelerates Induction of Adipose-Derived Stem Cells toward Schwann Cells through a Non-Smad Signaling Pathway.
Sawai S, Kishida T, Kotani SI, Tsuchida S, Oda R, Fujiwara H, Takahashi K, Mazda O, Sowa Y.
Stem Cells Int. 2021 Oct 15;2021:8307797. doi: 10.1155/2021/8307797. eCollection 2021. -
Extracellular acidity in tumor tissue upregulates PD-L1 expression on tumor cells via proton-sensing G protein-coupled receptors.
Mori, D., Tsujikawa, T., Sugiyama, Y., Kotani, S.-I., Fuse, S., Ohmura, G., Arai, A., Kawaguchi, T., Hirano, S., Mazda, O., Kishida, T.
Int J Cancer. 2021 Dec 15;149(12):2116-2124. doi: 10.1002/ijc.33786. Epub 2021 Sep 13. -
Osteogenic response to polysaccharide nanogel sheets of human fibroblasts after conversion into functional osteoblasts by direct phenotypic cell reprogramming
Nakai K., K. Yamamoto, T. Kishida, S.-I. Kotani, Y. Sato, S. Horiguchi, H. Yamanobe, T. Adachi, F. Boschetto, E. Marin, W. Zhu, T. Yamamoto, N. Kanamura, G. Pezzotti, O. Mazda
Front Bioeng Biotechnol. 2021 Sep 3;9:713932. doi: 10.3389/fbioe.2021.713932. eCollection 2021. -
Mechanisms of instantaneous inactivation of SARS-CoV-2 by silicon nitride bioceramic.
G. Pezzotti, F. Boschetto, E. Ohgitani, Y. Fujita, S. Shin-Ya, T. Adachi, T. Yamamoto, N. Kanamura, E. Marin, W. Zhu, I. Nishimura, O. Mazda
Mater Today Bio. 2021 Sep;12:100144. doi: 10.1016/j.mtbio.2021.100144. Epub 2021 Oct 1. -
Treadmill running prevents atrophy differently in fast- versus slow-twitch muscles in a rat model of rheumatoid arthritis.
Kamada Y, Toyama S, Arai Y, Inoue H, Nakagawa S, Fujii Y, Kaihara K, Kishida T, Mazda O, Takahashi K.
J Muscle Res Cell Motil. 2021 Dec;42(3-4):429-441. doi: 10.1007/s10974-021-09610-0. Epub 2021 Oct 23. PMID: 34687403 -
Rapid inactivation in vitro of SARS-CoV-2 in saliva by black tea and green tea
Ohgitani E, Shin-Ya M, Ichitani M, Kobayashi M, Takihara T, Kawamoto M, Kinugasa H, Mazda O.
Pathogens 2021, 10(6), 721; https://doi.org/10.3390/pathogens10060721 ⇐ （査読付国際科学雑誌、2021年6月公開）
bioRxiv 2020.12.28.424533; doi: https://doi.org/10.1101/2020.12.28.424533 ⇐ （プレプリント、2020年12月公開） -
Significant inactivation of SARS-CoV-2 by a green tea catechin, a catechin-derivative and galloylated theaflavins in vitro
Ohgitani E, Shin-Ya M, Ichitani M, Kobayashi M, Takihara T, Kawamoto M, Kinugasa H, Mazda O.
Molecules 2021, 26(12), 3572; https://doi.org/10.3390/molecules26123572 ⇐ （査読付国際科学雑誌、2021年6月公開）
bioRxiv 2020.12.04.412098; doi: https://doi.org/10.1101/2020.12.04.412098 ⇐ （プレプリント、2020年12月公開） -
Instantaneous "catch-and-kill" inactivation of SARS-CoV-2 by nitride ceramics.
Pezzotti G, Ohgitani E, Shin-Ya M, Adachi T, Marin E, Boschetto F, Zhu W, Mazda O.
Clin Transl Med. 2020 Oct;10(6):e212. doi: 10.1002/ctm2.212. -
Metabolic machinery encrypted in the Raman spectrum of influenza A virus-inoculated mammalian cells.
Pezzotti G, Zhu W, Adachi T, Horiguchi S, Marin E, Boschetto F, Ogitani E, Mazda O.
J Cell Physiol. 2020 Jun;235(6):5146-5170. doi: 10.1002/jcp.29392. Epub 2019 Nov 11.
PMID: 31710091 -
Pristimerin inhibits the proliferation of HT1080 fibrosarcoma cells by inducing apoptosis.
Hayashi D, Shirai T, Terauchi R, Tsuchida S, Mizoshiri N, Mori Y, Arai Y, Mazda O, Kubo T.
Oncol Lett. 2020 Apr;19(4):2963-2970. doi: 10.3892/ol.2020.11405. Epub 2020 Feb 17.
PMID: 32218852 -
Direct conversion of fibroblasts into urothelial cells that may be recruited to regenerating mucosa of injured urinary bladder.
Inoue Y, Kishida T, Kotani SI, Akiyoshi M, Taga H, Seki M, Ukimura O, Mazda O.
Sci Rep. 2019 Sep 25;9(1):13850. doi: 10.1038/s41598-019-50388-6. -
Involvement of PDGF-BB and IGF-1 in Activation of Human Schwann Cells by Platelet-Rich Plasma.
Sowa Y, Kishida T, Tomita K, Adachi T, Numajiri T, Mazda O.
Plast Reconstr Surg. 2019 Dec;144(6):1025e-1036e. doi: 10.1097/PRS.0000000000006266. -
Novel mesenchymal stem cell delivery system as targeted therapy against neuroblastoma using the TH-MYCN mouse model.
Maniwa J, Fumino S, Kimura K, Tanaka T, Higashi M, Kishida T, Mazda O, Tajiri T.
J Pediatr Surg. 2019 Dec;54(12):2600-2605. doi: 10.1016/j.jpedsurg.2019.08.023. Epub 2019 Aug 30. -
An intra-amniotic injection of mesenchymal stem cells promotes lung maturity in a rat congenital diaphragmatic hernia model.
Takayama S, Sakai K, Fumino S, Furukawa T, Kishida T, Mazda O, Tajiri T.
Pediatr Surg Int. 2019 Dec;35(12):1353-1361. doi: 10.1007/s00383-019-04561-7. Epub 2019 Sep 26. -
Treadmill Running in Established Phase Arthritis Inhibits Joint Destruction in Rat Rheumatoid Arthritis Models.
Fujii Y, Inoue H, Arai Y, Shimomura S, Nakagawa S, Kishida T, Tsuchida S, Kamada Y, Kaihara K, Shirai T, Terauchi R, Toyama S, Ikoma K, Mazda O, Mikami Y.
Int J Mol Sci. 2019 Oct 15;20(20):5100. doi: 10.3390/ijms20205100. -
Metabolic machinery encrypted in the Raman spectrum of influenza A virus-inoculated mammalian cells.
Pezzotti G, Zhu W, Adachi T, Horiguchi S, Marin E, Boschetto F, Ogitani E, Mazda O.
J Cell Physiol. 2020 Jun;235(6):5146-5170. doi: 10.1002/jcp.29392. Epub 2019 Nov 11. -
Pristimerin inhibits the proliferation of HT1080 fibrosarcoma cells by inducing apoptosis.
Hayashi D, Shirai T, Terauchi R, Tsuchida S, Mizoshiri N, Mori Y, Arai Y, Mazda O, Kubo T.
Oncol Lett. 2020 Apr;19(4):2963-2970. doi: 10.3892/ol.2020.11405. Epub 2020 Feb 17. -
Interferon-β signal may up-regulate PD-L1 expression through IRF9-dependent and independent pathways in lung cancer cells
Morimoto Y, Kishida T, Kotani S-I, Takayama K, Mazda O*
Biochem Biophys Res Commun. In press -
Nanogel tectonic porous 3D scaffold for direct reprogramming fibroblasts into osteoblasts and bone regeneration.
Sato Y, Yamamoto K, Horiguchi S, Tahara Y, Nakai K, Kotani SI, Oseko F, Pezzotti G, Yamamoto T, Kishida T, Kanamura N, Akiyoshi K*, Mazda O. *
Sci Rep. 2018 Oct 25;8(1):15824. doi: 10.1038/s41598-018-33892-z.
PMID: 30361649 -
Raman imaging of individual membrane lipids and deoxynucleoside triphosphates in living neuronal cells during neurite outgrowth.
Pezzotti G, Horiguchi S, Boschetto F, Adachi T, Marin E, Zhu W, Yamamoto T, Kanamura N, Ohgitani E, Mazda O.
ACS Chemical Neurosci. 2018 Jul 19. doi: 10.1021/acschemneuro.8b00235. [Epub ahead of print] PMID: 30024146 -
Development of a SiYAlON glaze for improved osteoconductivity of implantable medical devices.
Bock RM, Marin E, Rondinella A, Boschetto F, Adachi T, McEntire BJ, Bal BS, Pezzotti G.
J Biomed Mater Res B Appl Biomater 106 : 1084-1096. 2018. -
In vitro antibacterial activity of oxide and non-oxide bioceramics for arthroplastic devices: I. In situ time-lapse Raman spectroscopy.
Pezzotti G, Bock RM, McEntire BJ, Adachi T, Marin E, Boschetto F, Zhu W, Mazda O, Bal SB.
Analyst. 2018 Jul 23;143(15):3708-3721. doi: 10.1039/c8an00233a.
PMID: 29987284 -
Treadmill Running Ameliorates Destruction of Articular Cartilage and Subchondral Bone, Not Only Synovitis, in a Rheumatoid Arthritis Rat Model.
Shimomura S, Inoue H, Arai Y, Nakagawa S, Fujii Y, Kishida T, Ichimaru S, Tsuchida S, Shirai T, Ikoma K, Mazda O, Kubo T.
Int J Mol Sci. 2018 Jun 3;19(6). pii: E1653. doi: 10.3390/ijms19061653.
PMID: 29865282 3.226 -
Yamamoto K, Kishida T, Nakai K, Sato Y, Kotani S-I, Nishizawa Y, Yamamoto T, Kanamura N, & Mazda O.*
Direct phenotypic conversion of human fibroblasts into functional osteoblasts triggered by a blockade of the transforming growth factor-β signal
Scientific Reports May 31;8(1):8463. doi: 10.1038/s41598-018-26745-2.
PMID: 29855543 -
F. Boschetto, N. Toyama, S. Horiguchi, R. M. Bock, B. J. McEntire, T. Adachi, E. Marin, W. Zhu, O. Mazda, B. Sonny Bald, and G. Pezzotti*
In vitro antibacterial activity of oxide and non-oxide bioceramics for arthroplastic devices: II. Fourier transform infrared spectroscopy
Analyst. 2018 Apr 30;143(9):2128-2140. doi: 10.1039/c8an00234g.
PMID: 29666868 -
Pezzotti G, Marin E, Adachi T, Lerussi F, Rondinella A, Boschetto F, Zhu W, Kitajima T, Inada K, McEntire BJ, Bock RM, Bal BS, Mazda O.
Incorporating Si3N4 into PEEK to Produce Antibacterial, Osteocondutive, and Radiolucent Spinal Implants.
Macromol Biosci. 2018 Apr 24:e1800033. doi: 10.1002/mabi.201800033. [Epub ahead of print]
PMID: 29687593 -
Yamamoto H, Ueshima K, Saito M, Ikoma K, Ishida M, Goto T, Hayashi S, Ikegami A, Fujioka M, Mazda O, Kubo T.
Evaluation of femoral perfusion using dynamic contrast-enhanced MRI after simultaneous initiation of electrical stimulation and steroid treatment in an osteonecrosis model.
Electromagn Biol Med. 2018 Apr 30:1-11. doi: 10.1080/15368378.2018.1466310. [Epub ahead of print]
PMID: 29708772 -
Nakamura K, Kishida T, Ejima A, Tateyama R, Morishita S, Ono T, Murakoshi M, Sugiyama K, Nishino H, Mazda O.*
Bovine lactoferrin promotes energy expenditure via the cAMP-PKA signaling pathway in human reprogrammed brown adipocytes.
Biometals. 2018 May 9. doi: 10.1007/s10534-018-0103-9. [Epub ahead of print]
PMID: 29744695 -
Boschetto F, Adachi T, Horiguchi S, Fainozzi D, Parmigiani F, Marin E, Zhu W, McEntire B, Yamamoto T, Kanamura N, Mazda O, Ohgitani E, Pezzotti G.
Monitoring metabolic reactions in Staphylococcus epidermidis exposed to silicon nitride using in situ time-lapse Raman spectroscopy.
J Biomed Opt. 2018 May;23(5):1-10. doi: 10.1117/1.JBO.23.5.056002.
PMID: 29745132 -
Mori Y, Terauchi R, Shirai T, Tsuchida S, Mizoshiri N, Arai Y, Kishida T, Fujiwara H, Mazda O, Kubo T.
Suppression of heat shock protein 70 by siRNA enhances the antitumor effects of cisplatin in cultured human osteosarcoma cells.
Cell Stress Chaperones. 2017 Sep;22(5):699-706. doi: 10.1007/s12192-017-0793-x. Epub 2017 May 2. PMID: 28466152 -
G. Pezzotti*, R.M. Bock, T. Adachi, A. Rondinella, F. Boschetto, W. Zhu, E. Marin, B. McEntire, B. Sonny Bal, & O. Mazda
Silicon nitride surface chemistry: A potent regulator of mesenchymal progenitorcell activity in bone formation
Applied Materials Today 9: 82-95, 2017. https://doi.org/10.1016/j.apmt.2017.05.005 -
Mori Y, Shirai T, Terauchi R, Tsuchida S, Mizoshiri N, Hayashi D, Arai Y, Kishida T, Mazda O, & Kubo T
Antitumor effects of pristimerin on human osteosarcoma cells in vitro and in vivo
Onco Targets Ther. 28 November 2017 Volume 2017:10 Pages 5703—5710 -
Wakao J, Kishida T, Fumino S, Kimura K, Yamamoto K, Kotani S, Mizushima K, Naito Y, Yoshikawa T, Tajiri T, Mazda O.*
Efficient direct conversion of human fibroblasts into myogenic lineage induced by co-transduction with MYCL and MYOD1.
Biochem Biophys Res Commun. 2017 May 10. pii: S0006-291X(17)30921-X. doi: 10.1016/j.bbrc.2017.05.059. [Epub ahead of print]
PMID: 28501623 -
H. Tada, T. Kishida, H. Fujiwara, T. Kosuga, H. Konishi, S. Komatsu, A. Shiozaki, D. Ichikawa, K. Okamoto, E. Otsuji, & O. Mazda*
Reprogrammed chondrocytes engineered to produce interleukin-12 provide novel ex vivo immune-gene therapy for cancer
Immunotherapy. 2017 Mar;9(3):239-248. doi: 10.2217/imt-2016-0004.
PMID: 28231722 -
Sowa Y, Kishida T, Tomita K, Yamamoto K, Numajiri T, Mazda O.*
Direct Conversion of Human Fibroblasts into Schwann Cells that Facilitate Regeneration of Injured Peripheral Nerve In Vivo.
Stem Cells Transl Med. 2017 Apr;6(4):1207-1216. doi: 10.1002/sctm.16-0122. Epub 2017 Jan 9.
PMID: 28186702 -
Kimura K, Kishida T, Wakao J, Tanaka T, Higashi M, Fumino S, Aoi S, Furukawa T, Mazda O, Tajiri T.
Tumor-homing effect of human mesenchymal stem cells in a TH-MYCN mouse model of neuroblastoma.
J Pediatr Surg. 2016 Dec;51(12):2068-2073. doi: 10.1016/j.jpedsurg.2016.09.041.
PMID: 27686479 -
Ichimaru S, Nakagawa S, Arai Y*, Kishida T, Shin-Ya M, Honjo K, Tsuchida S, Inoue H, Fujiwara H, Shimomura S, Mazda O, Kubo T.
Hypoxia Potentiates Anabolic Effects of Exogenous Hyaluronic Acid in Rat Articular Cartilage.
Int J Mol Sci. 2016 Jun 25;17(7). pii: E1013. doi: 10.3390/ijms17071013.
PMID: 27347945 -
Kishida T, Ejima A, Mazda O*.
Specific Destruction of HIV Proviral p17 Gene in T Lymphoid Cells Achieved by the Genome Editing Technology.
Front Microbiol. 2016 Jun 28;7:1001. doi: 10.3389/fmicb.2016.01001. eCollection 2016.
PMID: 27446041 -
Yamamoto K., Sato Y., Honjo K., Ichioka H., Oseko F., Sowa Y., Yamamoto T., Kanamura N., Kishida T., Mazda O*
Generation of directly converted human osteoblasts that are free of exogenous gene and xenogenic protein
J Cell Biochem. 2016 Nov;117(11):2538-45. doi: 10.1002/jcb.25546. Epub 2016 Mar 31.
PMID: 26990860 -
Nishioka K, Kishida T, Masui S, Mazda O*
De novo CpG methylation on an artificial chromosome-like vector maintained for a long-term in mammalian cells.
Biotechnol Lett. 38 (4): 731-740, 2016. -
Mizoshiri N, Kishida T, Yamamoto K, Shirai T, Terauchi R, Tsuchida S, Mori Y, Ejima A, Sato Y, Arai Y, Fujiwara H, Yamamoto T, Kanamura N, Mazda O*, Kubo T.
Transduction of Oct6 or Oct9 gene concomitant with Myc family gene induced osteoblast-like phenotypic conversion in normal human fibroblasts.
Biochem Biophys Res Commun. 467 (4): 1110-1116, 2015. -
Yamamoto, K*. Yamamoto T, Honjo K, Ichioka H, Oseko F, Kishida T, Mazda O, & Kanamura N.
Electrical stimulation with periodic alternating intervals stimulates neuronal cells to produce neurotrophins and cytokines through activation of MAPK pathways.
Eur J Oral Sci. 123 (6): 403-408, 2015. -
Kishida T, Ejima A, Yamamoto K, Tanaka S, Yamamoto T, Mazda O*.
Reprogrammed Functional Brown Adipocytes Ameliorate Insulin Resistance and Dyslipidemia in Diet-Induced Obesity and Type 2 Diabetes.
Stem Cell Reports. 5 (4): 569-581, 2015. -
Sowa Y*. T. Kishida, T. Imura, T. Numajiri, K. Nishino, Y. Tabata, & O. Mazda
Adipose-derived stem cells promote peripheral nerve regeneration in vivo without differentiation into Schwann-like lineage.
Plast Reconstr Surg. 2016 Feb;137(2):318e-30e. -
Ichioka H, Yamamoto T, Yamamoto K, Honjo KI, Adachi T, Oseko F, Mazda O, Kanamura N, & Kita M*
Biomechanical force induces the growth factor production in human periodontal ligament-derived cells.
Odontology. 2016 Jan;104(1):27-34. -
Yamamoto K, Kishida T, Sato Y, Nishioka K, Ejima A, Fujiwara H, Kubo T, Yamamoto T, Kanamura N & Mazda O.*
Direct conversion of human fibroblasts into functional osteoblasts by defined factors.
Proc Natl Acad Sci USA. 2015 May 12;112(19):6152-7. -
Ikegami A, Ueshima K, Saito M, Ikoma K, Fujioka M, Hayashi S, Ishida M, Fujiwara H, Mazda O, Kubo T.
Femoral perfusion after pulsed electromagnetic field stimulation in a steroid-induced osteonecrosis model.
Bioelectromagnetics. 2015 Jul;36(5):349-57. -
Inoue H, Arai Y, Kishida T, Terauchi R, Honjo K, Nakagawa S, Tsuchida S, Matsuki T, Ueshima K, Fujiwara H, Mazda O, Kubo T.
Hydrostatic Pressure Influences HIF-2 Alpha Expression in Chondrocytes.
Int J Mol Sci. 2015 Jan 5;16(1):1043-50. -
Fujioka K, Kishida T, Ejima A, Yamamoto K, Fujii W, Murakami K, Seno T, Yamamoto A, Kohno M, Oda R, Yamamoto T, Fujiwara H, Kawahito Y, & Mazda O*.
Inhibition of osteoclastogenesis by osteoblast-like cells genetically engineered to produce interleukin-10.
Biochem Biophys Res Commun. 2015 Jan 16;456(3):785-91. -
Fujii H, Shin-Ya M, Takeda S, Hashimoto Y, Mukai S, Sawada S, Adachi T, Akiyoshi K*, Miki T, Mazda O*.
Cycloamylose-nanogel drug delivery system-mediated intratumor silencing of the vascular endothelial growth factor regulates neovascularization in tumor microenvironment
Cancer Sci. 105(12):1616-25, 2014. -
Honjo K, Yamamoto T, Adachi T, Amemiya T, Kita M, Kanamura N, and Mazda O.
Evaluation of a dental pulp-derived cell sheet cultured on amniotic membrane substrate
Biomed Mater Eng. 25(2): 203-12, 2015. -
Hayashi S, Fujioka M, Ikoma K, Saito M, Ueshima K, Ishida M, Kuribayashi M, Ikegami A, Mazda O, Kubo T.
Evaluation of femoral perfusion in a rabbit model of steroid-induced osteonecrosis by dynamic contrast-enhanced mri with a high magnetic field MRI system.
J Magn Reson Imaging. 41(4): 935-40, 2015. -
Tsuchida S, Arai Y, Takahashi KA, Kishida T, Terauchi R, Honjo K, Nakagawa S, Inoue H, Ikoma K, Ueshima K, Matsuki T, Mazda O, Kubo T.
HIF-1α-induced HSP70 regulates anabolic responses in articular chondrocytes under hypoxic conditions.
J Orthop Res. 32(8):975-80, 2014. -
Kami D, Kitani T, Kishida T, Mazda O, Toyoda M, Tomitaka A, Ota S, Ishii R, Takemura Y, Watanabe M, Umezawa A, Gojo S.
Pleiotropic functions of magnetic nanoparticles for ex vivo gene transfer. Nanomedicine. S1549-9634(14)00136-1, 2014.
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Inoue H, Arai Y, Kishida T, Shin-Ya, M, Terauchi R, Nakagawa S, Saito M, Tsuchida, S, Inoue A, Shirai T, Fujiwara H, Mazda O, Kubo T.
Sonoporation-mediated transduction of siRNA ameliorated experimental arthritis using 3 MHz pulsed ultrasound.
Ultrasonics. 54(3):874-81, 2013. -
Ohgitani E, Kita M, Mazda O, Imanishi J.
Combined administration of oseltamivir and hochu-ekki-to (TJ-41) dramatically decreases the viral load in lungs of senescence-accelerated mice during influenza virus infection.
Arch Virol. 159(2):267-75, 2013. -
Kishida T, Cui FD, Ohgitani E, Gao F, Hayakawa K, Mazda O.
High Pressure Treatment under Subfreezing Temperature Results in Drastic Inactivation of Enveloped and Non-enveloped Viruses.
Biotechnol Lett. 35(8):1297-301.2013. -
Nishigaki M, Yamamoto T, Ichioka H, Honjo KI, Yamamoto K, Oseko F, Kita M, Mazda O, Kanamura N.
β-cryptoxanthin regulates bone resorption related-cytokine production in human periodontal ligament cells.
Arch Oral Biol. 58(7):880-6, 2013. -
Hiraoka N, Arai Y, Takahashi KA, Mazda O, Kishida T, Honjo K, Tsuchida S, Inoue H, Morino S, Suico MA, Kai H, Kubo T.
Mild electrical stimulation with heat stimulation increase heat shock protein 70 in articular chondrocyte.
J Orthop Res. 31(6):894-900, 2013. -
Hagiwara K, Kishimoto S, Ishihara M, Koyama Y, Mazda O, Sato T.
*In vivo gene transfer using pDNA/chitosan/chondroitin sulfate ternary complexes: Influence of chondroitin sulfate on the stability of freeze-dried complexes and transgene expression in vivo.
J Gene Med.15(2):83-92, 2013. -
Gao F, Kishida T, Ejima A, Gojo S & Mazda O*.
Myostatin acts as an autocrine/paracrine negative regulator in myoblast differentiation from human induced pluripotent stem cells.
Biochem. Biophys. Res. Commun 8; 431(2): 309-14, 2013. -
Tsuchida S, Arai Y, Kishida T, Takahashi K, Honjo K, Terauchi R, Inoue H, Oda R, Mazda O, Kubo T.
Silencing the expression of connexin 43 decreases inflammation and joint destruction in experimental arthritis.
J. Orthop. Res. 31(4): 525-30, 2012. -
Toriumi Y*, Kamei T, Murata K, Takahashi I, Suzuki N, Mazda O.
Utility of Maoto in an Influenza Season where Reduced Effectiveness of Oseltamivir was Observed - a Clinical.
Non-randomized Study in Children Forsch Komplementmed. 19(4): 179-86, 2012. -
Nakagawa S, Arai Y*, Kishida T, Hiraoka N, Tsuchida S, Inoue H, Sakai R, Mazda O, Kubo T.
Lansoprazole Inhibits Nitric Oxide and Prostaglandin E(2) Production in Murine Macrophage RAW 264.7 Cells.
Inflammation.35(3): 1062-8, 2012 -
Fujita S, Arai Y*, Nakagawa S, Takahashi KA, Terauchi R, Inoue A, Tonomura H, Hiraoka N, Inoue H, Tsuchida S, Mazda O, Kubo T.
Combined microwave irradiation and intraarticular glutamine administration-induced HSP70 expression therapy prevents cartilage degradation in a rat osteoarthritis model.
J Orthop Res. 30(3): 401-7, 2011. -
Yamamoto K*, Yamamoto T, Ichioka H, Akamatsu Y, Oseko F, Mazda O, Imanishi J, Kanamura N, Kita M.
Effects of mechanical stress on cytokine production in mandible-derived osteoblasts.
Oral Dis. 17(7): 712-9, 2011. -
Yoshimoto K, Kishida T, Nakano Hi, Matsui M, Shin-Ya M, Shimada T, Nakai S, Imanishi J, Takeuchi M, Hisa Y, Mazda O.
Interleukin-28B acts synergistically with cisplatin to suppress the growth of head and neck squamous cell carcinoma.
J Immunother 34: 139-148, 2011 -
Hiraoka N, Takahashi KA, Arai Y, Sakao K, Mazda O, Kishida T, Honjo K, Tanaka S, Kubo T.
Intra-articular injection of hyaluronan restores the aberrant expression of matrix metalloproteinase-13 in osteoarthritic subchondral bone.
J Orthop Res 29: 354-360, 2010. -
Shinoda M, Shin-Ya M, Naito Y, Kishida T, Ito R, Suzuki N, Yasuda H, Sakagami J, Imanishi J, Kataoka K, Mazda O, Yoshikawa T.
Early-stage blocking of Notch signaling inhibits the depletion of goblet cells in dextran sodium sulfate-induced colitis in mice.
J Gastroenterol. 45: 608-617, 2010. -
Nakai N, Kishida T, Hartmann G, Katoh N, Imanishi J, Kishimoto S, Mazda O.
Mitf silencing cooperates with IL-12 gene transfer to inhibit melanoma in mice.
Int Immunopharmacol 10: 540-545, 2010. -
Honjo K, Takahashi KA, Mazda O, Kishida T, Shin-Ya M, Tokunaga D, Arai Y, Inoue A, Hiraoka N, Imanishi J, Kubo T.
MDR1a/1b gene silencing enhances drug sensitivity in rat fibroblast-like synoviocytes.
J Gene Med 12: 219-227, 2010. -
Nakagawa S, Arai Y, Mazda O, Kishida T, Takahashi KA, Sakao K, Saito M, Honjo K, Imanishi J, Kubo T.
N-acetylcysteine prevents nitric oxide-induced chondrocyte apoptosis and cartilage degeneration in an experimental model of osteoarthritis.
J Orthop Res 28: 156-163, 2010. -
Sakao K, Takahashi KA, Arai Y, Saito M, Honjo K, Hiraoka N, Kishida T, Mazda O, Imanishi J, Kubo T.
Asporin and transforming growth factor-β gene expression in osteoblasts from subchondral bone and osteophytes in osteoarthritis.
J Orthop Sci 14: 738-747, 2009. -
Hasegawa U, Sawada SI, Shimizu T, Kishida T, Otsuji E, Mazda O, Akiyoshi K.
Raspberry-like assembly of cross-linked nanogels for protein delivery.
J Control Release 140: 312-317, 2009. -
Hashimoto T, Tachibana Y, Nozaki H, Mazda O, Niidome T, Murakami A, Yamaoka T.
Intracellular enzyme-responsive fragmentation of nonviral gene carriers leads to polyplex destabilization and enhanced transgene expression.
Chem Lett 38: 718-719. 2009. -
Matsui M, Kishida T, Nakano H, Yoshimoto K, Shin-Ya M, Shimada T, Nakai S, Imanishi J, Yoshimoto T, Hisa Y, Mazda O.
Interleukin-27 activates natural killer cells and suppresses NK-resistant head and neck squamous cell carcinoma through inducing antibody-dependent cellular cytotoxicity.
Cancer Res 69: 2523-2530, 2009. -
Sakao K, Takahashi KA, Arai Y, Saito M, Honjo K, Hiraoka N, Asada H, Shin-Ya M, Imanishi J, Mazda O, Kubo T.
Osteoblasts derived from osteophytes produce inteleukin-6, interleukin-8 and matrix metalloproteinase-13 in osteoarthritis.
J Bone Miner Metab 27: 412-423, 2009. -
Inoue A, Takahashi KA, Mazda O, Arai Y, Saito M, Kishida T, Shin-Ya M, Morihara T, Tonomura H, Sakao K, Imanishi J, Kubo T.
Comparison of anti-rheumatic effects of local RNAi-based Therapy in collagen induced arthritis rats using various cytokine genes as molecular targets.
Mod Rheumatol 19: 125-133, 2009. -
Nakai N, Katoh N, Germeraad WTV, Kishida T, Ueda E, Takenaka H, Mazda O, Kishimoto S.
Immunohistological analysis of peptide-induced delayed-type hypersensitivity in advanced melanoma patients treated with melanoma antigen-pulsed mature monocyte-derived dendritic cell vaccination.
J Dermatol Sci 53: 40-47, 2009. -
Ito R, Kita M, Shin-Ya M, Kishida T, Urano A, Takada R, Sakagami J, Imanishi J, Iwakura Y, Okanoue T, Yoshikawa T, Kataoka K, Mazda O.
Involvement of IL-17A in the pathogenesis of DSS-induced colitis in mice.
Biochem Biophys Res Commun 377: 12-16, 2008. -
Sakao K, Takahashi KA, Arai Y, Inoue A, Tonomura H, Saito M, Yamamoto T, Kanamura N, Imanishi J, Mazda O, Kubo T.
Induction of chondrogenic phenotype in synovium-derived progenitor cells by intermittent hydrostatic pressure.
Osteoarthr Cartilage 16: 805-814, 2008. -
Sakao K, Takahashi KA, Mazda O, Arai Y, Tonomura H, Inoue A, Saito M, Fujioka M, Takamiya H, Imanishi J, Kubo T.
Enhanced expression of interleukin-6, matrix metalloproteinase-13, and receptor activator of NF-kappaB ligand in cells derived from osteoarthritic subchondral bone.
J Orthop Sci 13: 202-210, 2008. -
Shimizu T, Kishida T, Hasegawa U, Ueda Y, Imanishi J, Yamagishi H, Akiyoshi K, Otsuji E, Mazda O.
Nanogel DDS enables sustained release of IL-12 for tumor immunotherapy.
Biochem Biophys Res Commun 367: 330-335, 2008. -
Kishida T, Asada H, Kubo K, Sato Y, Shin-Ya M, Imanishi J, Yoshikawa K, Mazda O.
Pleiotrophic functions of Epstein-Barr virus nuclear antigen-1 (EBNA-1) and oriP differentially contribute to the efficacy of transfection/expression of exogenous gene in mammalian cells.
J Biotechnol 133: 201-207, 2008. -
Tonomura H, Takahashi KA, Mazda O, Arai Y, Shin-Ya M, Inoue A, Honjo K, Hojo T, Imanishi J, Kubo T.
Effects of heat stimulation via microwave applicator on cartilage matrix gene and HSP70 expression in the rabbit knee joint.
J Orthop Res 26: 34-41, 2008. -
Kishida T, Hiromura Y, Shin-Ya M, Asada H, Kuriyama H, Sugai M, Shimizu A, Yokota Y, Hama T, Imanishi J, Hisa Y, Mazda O.
IL-21 induces inhibitor of differentiation 2 (Id2) and leads to complete abrogation of anaphylaxis in mice.
J Immunol 179: 8554-8561, 2007. -
Hiromura Y, Kishida T, Nakano H, Hama T, Imanishi J, Hisa Y, Mazda O.
IL-21 administration into the nostril alleviates murine allergic rhinitis.
J Immunol 179: 7157-7165, 2007. -
Saito M, Mazda O, Takahashi KA, Arai Y, Kishida T, Shin-Ya M, Inoue A, Tonomura H, Sakao K, Morihara T, Imanishi J, Kawata M, Kubo T.
Sonoporation-mediated transduction of pDNA/siRNA into joint synovium in vivo.
J Orthop Res 25: 1308-1316, 2007. -
Nakai N, Kishida T, Shin-Ya M, Imanishi J, Ueda Y, Kishimoto S, Mazda O.
Therapeutic RNA interference of malignant melanoma by electrotransfer of small interfering RNA targeting Mitf.
Gene Ther 14: 357-365, 2007. -
Ishii M, Iwai M, Harada Y, Kishida T, Asada H, Shin-Ya M, Itoh Y, Imanishi J, Okanoue T, Mazda O.
Soluble TRAIL gene and actinomycin D synergistically suppressed multiple metastasis of TRAIL-resistant colon cancer in the liver.
Cancer Letters 245: 134-143, 2007. -
Ito R, Shin-Ya M, Kishida T, Urano A, Takada R, Sakagami J, Imanishi J, Kita M, Ueda Y, Iwakura Y, Kataoka K, Okanoue T, Mazda O.
Interferon-gamma is Causatively involved in experimental inflammatory bowel disease in mice.
Exp Clin Immunol 146: 330-338, 2006. -
Iida Y, Oda Y, Nakamori S, Tsunoda S, Kishida T, Gojo S, Shin-Ya M, Asada H, Imanishi J, Yoshikawa T, Matsubara H, Mazda O.
Transthoracic direct current (DC) shock facilitates intramyocardial transfection of naked plasmid DNA infused via coronary vessels in canines.
Gene Ther 13: 906-916, 2006. - Tonomura H, Takahashi KA, Mazda O, Arai Y, Inoue A, Terauchi R, Shin-Ya M, Kishida T, Imanishi J, Kubo
T.
Glutamine protects articular chondrocytes from heat stress and NO-induced apoptosis with HSP70 expression.
Osteoarthr Cartilage 14: 545-553, 2006. -
Asada H, Kishida T, Hirai H, Shin-Ya M, Imanishi J, Takeuchi M, Mazda O.
Combination vaccine of dendritic Cells (DCs) and T cells effectively suppressed preestablished malignant melanoma in mice.
Cancer Letters 240: 83-93, 2006. -
Nakano H, Kishida T, Asada H, Shin-Ya M, Shinomiya T, Imanishi J, Shimada T, Nakai S, Takeuchi M, Hisa Y and Mazda O.
Interleukin-21 triggers both cellular and humoral immune responses leading to therapeutic antitumor effects against head and neck squamous cell carcinoma.
J Gene Med 8: 90-99, 2006.